Research Articles
The Secret Code of Cellular Destruction: How UBR E3 Ligases Choose Their Targets
Discover how UBR E3 ligases identify proteins for destruction through the N-degron pathway and the groundbreaking discovery of an alternative binding pocket.
Unlocking Nature's Pharmacy: How a Traditional Medicine Plant Regulates Its Healing Compounds
Discover how Uncaria rhynchophylla regulates medicinal compounds through SINA E3 ubiquitin ligases - a breakthrough in plant genomics and traditional medicine.
The Ubiquitin Enigma: How a Tiny Potato Protein Holds the Key to Future Crops
Discover how potato E2 enzymes in the ubiquitin-proteasome pathway could revolutionize crop resilience and global food security.
Beyond Destruction: The Surprising Dual Life of the Hakai Protein
Discover the fascinating dual roles of Hakai protein - from cellular destruction to mRNA regulation and its implications for cancer research.
The Ubiquitin Editor: How USP5 Controls Your Immune System and Fights Disease
Discover how USP5, a cellular ubiquitin editor, regulates immune pathways and offers promising therapeutic potential for cancer, viral infections, and leukemia.
Disarming Bone Cancer: How Hijacking Cellular Recycling Fights Osteosarcoma
Discover how targeting the E3 ubiquitin ligase CBL offers promising new approaches to fight osteosarcoma by reprogramming cellular recycling systems.
Beyond Kinase Inhibition: The Unexpected Role of Ubiquitin in BCR-ABL Leukemogenesis
Exploring how ubiquitin-mediated interactions serve as BCR-ABL's accomplice in leukemogenesis, opening new therapeutic avenues for CML treatment.
The CUL4-RING E3 Ubiquitin Ligases: Master Conductors of Cellular Destiny
Explore the research progress of CUL4-RING E3 ubiquitin ligases, their role in cellular processes, therapeutic applications, and recent scientific discoveries.
How Legionella Bacteria Hijack Our Cellular Defense System: The Ubiquitin Story
Explore how Legionella pneumophila manipulates the ubiquitin system to survive and thrive in eukaryotic host cells through sophisticated molecular piracy.
SOCS6: The Master Regulator of Cellular Signaling and Its Role in the E3 Ubiquitin Ligase Complex
Explore SOCS6's role as a cellular conductor regulating protein destruction through the E3 ubiquitin ligase complex, with implications for cancer, metabolism and autoimmune diseases.